Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-9 (of 9 Records) |
Query Trace: Escobedo M[original query] |
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Response to Escobedo et al
Beer KD , Collier SA , Du F , Gargano JW . Clin Infect Dis 2018 67 (3) 481 We were pleased to receive the response from Escobedo, et al to our recent manuscript describing giardiasis diagnosis and treatment patterns in the United States. They shared a summary of similar diagnosis and treatment patterns among giardiasis patients in Cuba, notably, that diagnoses are often delayed. They offer a framework for understanding and addressing these patterns based on surveys conducted among Cuban patients, caregivers and physicians. We wish to thank them for their insights, and highlight opportunities for US clinical and public health professionals to explore and address factors underlying delayed diagnoses and ineffective treatment in this country. |
Antibody responses against Anopheles darlingi immunogenic peptides in plasmodium infected humans
Londono-Renteria B , Montiel J , Calvo E , Tobón-Castaño A , Valdivia HO , Escobedo-Vargas K , Romero L , Bosantes M , Fisher ML , Conway MJ , Vásquez GM , Lenhart AE . Front Cell Infect Microbiol 2020 10 455 Introduction: Malaria is still an important vector-borne disease in the New World tropics. Despite the recent decline in malaria due to Plasmodium falciparum infection in Africa, a rise in Plasmodium infections has been detected in several low malaria transmission areas in Latin America. One of the main obstacles in the battle against malaria is the lack of innovative tools to assess malaria transmission risk, and the behavioral plasticity of one of the main malaria vectors in Latin America, Anopheles darlingi. Methods: We used human IgG antibodies against mosquito salivary gland proteins as a measure of disease risk. Whole salivary gland antigen (SGA) from Anopheles darlingi mosquitoes was used as antigen in Western blot experiments, in which a ~65 kDa protein was visualized as the main immunogenic band and sent for sequencing by mass spectrometry. Apyrase and peroxidase peptides were designed and used as antigens in an ELISA-based test to measure human IgG antibody responses in people with different clinical presentations of malaria. Results: Liquid chromatography–mass spectrometry revealed 17 proteins contained in the ~65 kDa band, with an apyrase and a peroxidase as the two most abundant proteins. Detection of IgG antibodies against salivary antigens by ELISA revealed a significant higher antibody levels in people with malaria infection when compared to uninfected volunteers using the AnDar_Apy1 and AnDar_Apy2 peptides. We also detected a significant positive correlation between the anti-peptides IgG levels and antibodies against the Plasmodium vivax and P. falciparum antigens PvMSP1 and PfMSP1. Odd ratios suggest that people with higher IgG antibodies against the apyrase peptides were up to five times more likely to have a malaria infection. Conclusion: Antibodies against salivary peptides from An. darlingi salivary gland proteins may be used as biomarkers for malaria risk. |
High birth weight, early UV exposure, and melanoma risk in children, adolescents and young adults
Wojcik KY , Escobedo LA , Wysong A , Heck JE , Ritz B , Hamilton AS , Milam J , Cockburn MG . Epidemiology 2018 30 (2) 278-284 BACKGROUND: Melanoma, the deadliest form of skin cancer, is the second most common cancer diagnosed before age 30. Little is known about potentially modifiable or intervenable risk factors specific to developing melanoma at a young age. The objective was to determine if high birth weight or higher early life ultraviolet (UV) radiation exposure would be associated with increased risk of melanoma in young patients. METHODS: Population-based, case-control study of 1,396 cases of melanoma diagnosed before age 30 in 1988-2013 and 27,920 controls, obtained by linking cancer registry data to birth records in California. RESULTS: High birth weight (>4000g) was associated with 19% higher risk of melanoma (OR:1.19; 95% CI: 1.02, 1.39), while low birth weight (<2500g) was associated with 41% lower risk (OR:0.59; 95% CI: 0.43, 0.82), compared to normal birth weight (2500-4000g); dose-response per 1000g increase was also evident (OR:1.24; 95% CI:1.13, 1.36). All quartiles of birthplace UV greater than the lowest quartile were associated with increased melanoma risk. The strongest relationship between birthplace UV and melanoma was for 15-19 years of age at diagnosis. CONCLUSIONS: High birth weight and high early-life UV exposure may be important independent risk factors for melanoma diagnosis before age 30. The implication is that adopting skin-protective behaviors as early as infancy could be important for primary prevention of melanoma in younger people. However, research that accounts for early-life behavioral patterns of skin protection during infancy is needed to advance our understanding of how birth weight and early-life UV may influence development of early onset melanoma. |
Border lookout: enhancing tuberculosis control on the United States-Mexico border
DeSisto C , Broussard K , Escobedo M , Borntrager D , Alvarado-Ramy F , Waterman S . Am J Trop Med Hyg 2015 93 (4) 747-51 We evaluated the use of federal public health intervention tools known as the Do Not Board and Border Lookout (BL) for detecting and referring infectious or potentially infectious land border travelers with tuberculosis (TB) back to treatment. We used data about the issuance of BL from April 2007 to September 2013 to examine demographics and TB laboratory results for persons on the list (N = 66) and time on the list before being located and achieving noninfectious status. The majority of case-patients were Hispanic and male, with a median age of 39 years. Most were citizens of the United States or Mexico, and 30.3% were undocumented migrants. One-fifth had multidrug-resistant TB. Nearly two-thirds of case-patients were located and treated as a result of being placed on the list. However, 25.8% of case patients, primarily undocumented migrants, remain lost to follow-up and remain on the list. For this highly mobile patient population, the use of this novel federal travel intervention tool facilitated the detection and treatment of infectious TB cases that were lost to follow-up. |
Obstetric emergencies at the United States-Mexico border crossings in El Paso, Texas
McDonald JA , Rishel K , Escobedo MA , Arellano DE , Cunningham TJ . Rev Panam Salud Publica 2015 37 (2) 76-82 OBJECTIVE: To describe the frequency, characteristics, and patient outcomes for women who accessed Emergency Medical Services (EMS) for obstetric emergencies at the ports of entry (POE) between El Paso, Texas, United States of America, and Ciudad Juarez, Chihuahua, Mexico. METHODS: A descriptive study of women 12-49 years of age for whom an EMS ambulance was called to an El Paso POE location from December 2008-April 2011 was conducted. Women were identified through surveillance of EMS records. EMS and emergency department (ED) records were abstracted for all women through December 2009 and for women with an obstetric emergency through April 2011. For obstetric patients admitted to the hospital, additional prenatal and birth characteristics were collected. Frequencies and proportions were estimated for each variable; differences between residents of the United States and Mexico were tested. RESULTS: During December 2008-December 2009, 47.6% (68/143) of women receiving EMS assistance at an El Paso POE had an obstetric emergency, nearly 20 times the proportion for Texas overall. During December 2008-April 2011, 60.1% (66/109) of obstetric patients with ED records were admitted to hospital and 52 gave birth before discharge. Preterm birth (23.1%; No. = 12), low birth weight (9.6%; No. = 5), birth in transit (7.7%; No. = 4), and postpartum hemorrhage (5.8%; No. = 3) were common; fewer than one-half the women (46.2%; No. = 24) had evidence of prenatal care. CONCLUSIONS: The high proportion of obstetric EMS transports and high prevalence of complications in this population suggest a need for binational risk reduction efforts. |
Civil surgeon tuberculosis evaluations for foreign-born persons seeking permanent U.S. residence
Bemis K , Thornton A , Rodriguez-Lainz A , Lowenthal P , Escobedo M , Sosa LE , Tibbs A , Sharnprapai S , Moser KS , Cochran J , Lobato MN . J Immigr Minor Health 2015 18 (2) 301-7 Foreign-born persons in the United States seeking to adjust their status to permanent resident must undergo screening for tuberculosis (TB) disease. Screening is performed by civil surgeons (CS) following technical instructions by the Centers for Disease Control and Prevention. From 2011 to 2012, 1,369 practicing CS in California, Texas, and New England were surveyed to investigate adherence to the instructions. A descriptive analysis was conducted on 907 (66 %) respondents. Of 907 respondents, 739 (83 %) had read the instructions and 565 (63 %) understood that a chest radiograph is required for status adjustors with TB symptoms; however, only 326 (36 %) knew that a chest radiograph is required for immunosuppressed status adjustors. When suspecting TB disease, 105 (12 %) would neither report nor refer status adjustors to the health department; 91 (10 %) would neither start treatment nor refer for TB infection. Most CS followed aspects of the technical instructions; however, educational opportunities are warranted to ensure positive patient outcomes. |
Notes from the field: measles transmission at a domestic terminal gate in an international airport - United States, January 2014
Vega JS , Escobedo M , Schulte CR , Rosen JB , Schauer S , Wiseman R , Lippold SA , Regan JJ . MMWR Morb Mortal Wkly Rep 2014 63 (50) 1211 In March 2014, CDC identified a possible cluster of four laboratory-confirmed measles cases among passengers transiting a domestic terminal in a U.S. international airport. Through epidemiologic assessments conducted by multiple health departments and investigation of flight itineraries by CDC, all four patients were linked to the same terminal gate during a 4-hour period on January 17, 2014. Patient 1, an unvaccinated man aged 21 years with rash onset February 1, traveled on two domestic flights on January 17 and 18 that connected at the international airport. Patient 2, an unvaccinated man aged 49 years with rash onset February 1, traveled from the airport on January 17. Patient 3, an unvaccinated man aged 19 years with rash onset January 30, traveled domestically with at least a 4-hour layover at the airport on January 17. Patient 4, an unvaccinated man aged 63 years with rash onset February 5, traveled on a flight to the airport on January 17. |
Actions to control high blood pressure among hypertensive adults in Texas counties along the Mexico border: Texas BRFSS, 2007
Ayala C , Fang J , Escobedo L , Pan S , Balcazar HG , Wang G , Merritt R . Public Health Rep 2012 127 (2) 173-85 OBJECTIVES: We examined the prevalence of actions taken to control blood pressure as measured by taking antihypertensive medication or making lifestyle modifications among hypertensive adults residing along the Texas/Mexico border. METHODS: We used self-reported data from the 2007 Texas Behavioral Risk Factor Surveillance System, with oversampling of border counties. We calculated the age-standardized prevalence of actions taken to control hypertension by selected characteristics. RESULTS: In analyses that combined ethnicity with predominant language spoken, those least likely to take any action to control their blood pressure-either by taking an antihypertensive medication or by making any of four lifestyle modifications-were Spanish-speaking Hispanic people (83.2% +/- 2.7% standard error [SE]), with English-speaking non-Hispanic people (88.9% +/- 0.8% SE) having the highest prevalence of taking action to control blood pressure. When analyzed by type of medical category, uninsured Hispanic people (63.8% +/- 4.8% SE) had the lowest prevalence of taking action to control their blood pressure compared with uninsured non-Hispanic people (75.4% +/- 4.7% SE). Nonborder Texas residents with hypertension were more likely to take antihypertensive medications (78.4% +/- 1.0% SE) than border county residents with hypertension (70.7% +/- 2.0% SE). CONCLUSIONS: Public health efforts must be undertaken to improve the control of hypertension among residents of Texas counties along the Mexico border, particularly for uninsured Hispanic people. |
Outcomes of multidrug-resistant tuberculosis among binational cases in El Paso, Texas
Ferrer G , Acuna-Villaorduna C , Escobedo M , Vlasich E , Rivera M . Am J Trop Med Hyg 2010 83 (5) 1056-8 In the United States, multidrug-resistant tuberculosis (MDR-TB) is more commonly seen among foreign-born patients. We report outcomes for 46 patients with MDR-TB who were born in Mexico and treated along the United States-Mexico border. According to our definition, 30 were cured, 3 showed treatment failure, 3 died, and 10 abandoned treatment. Multidrug-resistant tuberculosis can be successfully treated on an ambulatory basis. |
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